An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides

Heterocycle-containing cyclic peptides are promising scaffolds for the pharmaceutical industry but their chemical synthesis is very challenging. A new universal method has been devised to prepare these compounds by using a set of engineered marine-derived enzymes and substrates obtained from a famil...

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Detalles Bibliográficos
Autores principales: Houssen, Wael E, Bent, Andrew F, McEwan, Andrew R, Pieiller, Nathalie, Tabudravu, Jioji, Koehnke, Jesko, Mann, Greg, Adaba, Rosemary I, Thomas, Louise, Hawas, Usama W, Liu, Huanting, Schwarz-Linek, Ulrich, Smith, Margaret C M, Naismith, James H, Jaspars, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282754/
https://www.ncbi.nlm.nih.gov/pubmed/25331823
http://dx.doi.org/10.1002/anie.201408082

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