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Prevention of 5-hydroxytryptamine(2C) receptor RNA editing and alternate splicing in C57BL/6 mice activates the hypothalamic-pituitary-adrenal axis and alters mood

The 5-hydroxytryptamine(2C) (5-HT)(2C) receptor is widely implicated in the aetiology of affective and eating disorders as well as regulation of the hypothalamo-pituitary-adrenal axis. Signalling through this receptor is regulated by A-to-I RNA editing, affecting three amino acids in the protein seq...

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Detalles Bibliográficos
Autores principales: Bombail, Vincent, Qing, Wei, Chapman, Karen E, Holmes, Megan C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282755/
https://www.ncbi.nlm.nih.gov/pubmed/25257581
http://dx.doi.org/10.1111/ejn.12727