Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease

BACKGROUND/AIMS: C-reactive protein (CRP) is a serologic activity marker in Crohn’s disease (CD), but it may be less useful in evaluating CD activity in ileal CD patients. We aimed to investigate the usefulness of CRP as a disease activity marker in CD according to disease location. METHODS: Korean...

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Autores principales: Yang, Dong-Hoon, Yang, Suk-Kyun, Park, Sang Hyoung, Lee, Ho-Su, Boo, Sun-Jin, Park, Jae-Ho, Na, Soo Young, Jung, Kee Wook, Kim, Kyung-Jo, Ye, Byong Duk, Byeon, Jeong-Sik, Myung, Seung-Jae, Kim, Jin-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Gut and Liver 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282861/
https://www.ncbi.nlm.nih.gov/pubmed/25170056
http://dx.doi.org/10.5009/gnl13424
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author Yang, Dong-Hoon
Yang, Suk-Kyun
Park, Sang Hyoung
Lee, Ho-Su
Boo, Sun-Jin
Park, Jae-Ho
Na, Soo Young
Jung, Kee Wook
Kim, Kyung-Jo
Ye, Byong Duk
Byeon, Jeong-Sik
Myung, Seung-Jae
Kim, Jin-Ho
author_facet Yang, Dong-Hoon
Yang, Suk-Kyun
Park, Sang Hyoung
Lee, Ho-Su
Boo, Sun-Jin
Park, Jae-Ho
Na, Soo Young
Jung, Kee Wook
Kim, Kyung-Jo
Ye, Byong Duk
Byeon, Jeong-Sik
Myung, Seung-Jae
Kim, Jin-Ho
author_sort Yang, Dong-Hoon
collection PubMed
description BACKGROUND/AIMS: C-reactive protein (CRP) is a serologic activity marker in Crohn’s disease (CD), but it may be less useful in evaluating CD activity in ileal CD patients. We aimed to investigate the usefulness of CRP as a disease activity marker in CD according to disease location. METHODS: Korean CD patients in a single hospital were evaluated. Factors associated with elevated CRP concentration at the time of diagnosis of CD and the association between the physician’s prediction regarding upcoming surgery and the sites of the lesions directly related to surgery were analyzed. RESULTS: Of 435 CD patients, 25.7%, 6.9%, and 67.4% had ileal, colonic, and ileocolonic CD, respectively. Multivariate analysis revealed that an elevated erythrocyte sedimentation rate, reduced serum albumin, CD activity index (CDAI) >220, and ileocolonic/colonic location were associated with an elevated CRP level and that the CRP level was significantly correlated with the CDAI in all CD patients (γ=0.466, p<0.01). However, the correlation coefficient was dependent on the location, with values of 0.395, 0.456, and 0.527 in patients with an ileal, ileocolonic, and colonic disease location, respectively. Surgery for ileal lesions was less predictable than surgery for ileocolonic or colonic lesions during follow-up. CONCLUSIONS: CRP is less useful as a disease activity marker in patients with ileal CD than those with ileocolonic or colonic CD.
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spelling pubmed-42828612015-01-09 Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease Yang, Dong-Hoon Yang, Suk-Kyun Park, Sang Hyoung Lee, Ho-Su Boo, Sun-Jin Park, Jae-Ho Na, Soo Young Jung, Kee Wook Kim, Kyung-Jo Ye, Byong Duk Byeon, Jeong-Sik Myung, Seung-Jae Kim, Jin-Ho Gut Liver Original Article BACKGROUND/AIMS: C-reactive protein (CRP) is a serologic activity marker in Crohn’s disease (CD), but it may be less useful in evaluating CD activity in ileal CD patients. We aimed to investigate the usefulness of CRP as a disease activity marker in CD according to disease location. METHODS: Korean CD patients in a single hospital were evaluated. Factors associated with elevated CRP concentration at the time of diagnosis of CD and the association between the physician’s prediction regarding upcoming surgery and the sites of the lesions directly related to surgery were analyzed. RESULTS: Of 435 CD patients, 25.7%, 6.9%, and 67.4% had ileal, colonic, and ileocolonic CD, respectively. Multivariate analysis revealed that an elevated erythrocyte sedimentation rate, reduced serum albumin, CD activity index (CDAI) >220, and ileocolonic/colonic location were associated with an elevated CRP level and that the CRP level was significantly correlated with the CDAI in all CD patients (γ=0.466, p<0.01). However, the correlation coefficient was dependent on the location, with values of 0.395, 0.456, and 0.527 in patients with an ileal, ileocolonic, and colonic disease location, respectively. Surgery for ileal lesions was less predictable than surgery for ileocolonic or colonic lesions during follow-up. CONCLUSIONS: CRP is less useful as a disease activity marker in patients with ileal CD than those with ileocolonic or colonic CD. Gut and Liver 2015-01 2014-04-23 /pmc/articles/PMC4282861/ /pubmed/25170056 http://dx.doi.org/10.5009/gnl13424 Text en Copyright © 2015 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yang, Dong-Hoon
Yang, Suk-Kyun
Park, Sang Hyoung
Lee, Ho-Su
Boo, Sun-Jin
Park, Jae-Ho
Na, Soo Young
Jung, Kee Wook
Kim, Kyung-Jo
Ye, Byong Duk
Byeon, Jeong-Sik
Myung, Seung-Jae
Kim, Jin-Ho
Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease
title Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease
title_full Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease
title_fullStr Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease
title_full_unstemmed Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease
title_short Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease
title_sort usefulness of c-reactive protein as a disease activity marker in crohn’s disease according to the location of disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282861/
https://www.ncbi.nlm.nih.gov/pubmed/25170056
http://dx.doi.org/10.5009/gnl13424
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