Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease
BACKGROUND/AIMS: C-reactive protein (CRP) is a serologic activity marker in Crohn’s disease (CD), but it may be less useful in evaluating CD activity in ileal CD patients. We aimed to investigate the usefulness of CRP as a disease activity marker in CD according to disease location. METHODS: Korean...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Gut and Liver
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282861/ https://www.ncbi.nlm.nih.gov/pubmed/25170056 http://dx.doi.org/10.5009/gnl13424 |
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author | Yang, Dong-Hoon Yang, Suk-Kyun Park, Sang Hyoung Lee, Ho-Su Boo, Sun-Jin Park, Jae-Ho Na, Soo Young Jung, Kee Wook Kim, Kyung-Jo Ye, Byong Duk Byeon, Jeong-Sik Myung, Seung-Jae Kim, Jin-Ho |
author_facet | Yang, Dong-Hoon Yang, Suk-Kyun Park, Sang Hyoung Lee, Ho-Su Boo, Sun-Jin Park, Jae-Ho Na, Soo Young Jung, Kee Wook Kim, Kyung-Jo Ye, Byong Duk Byeon, Jeong-Sik Myung, Seung-Jae Kim, Jin-Ho |
author_sort | Yang, Dong-Hoon |
collection | PubMed |
description | BACKGROUND/AIMS: C-reactive protein (CRP) is a serologic activity marker in Crohn’s disease (CD), but it may be less useful in evaluating CD activity in ileal CD patients. We aimed to investigate the usefulness of CRP as a disease activity marker in CD according to disease location. METHODS: Korean CD patients in a single hospital were evaluated. Factors associated with elevated CRP concentration at the time of diagnosis of CD and the association between the physician’s prediction regarding upcoming surgery and the sites of the lesions directly related to surgery were analyzed. RESULTS: Of 435 CD patients, 25.7%, 6.9%, and 67.4% had ileal, colonic, and ileocolonic CD, respectively. Multivariate analysis revealed that an elevated erythrocyte sedimentation rate, reduced serum albumin, CD activity index (CDAI) >220, and ileocolonic/colonic location were associated with an elevated CRP level and that the CRP level was significantly correlated with the CDAI in all CD patients (γ=0.466, p<0.01). However, the correlation coefficient was dependent on the location, with values of 0.395, 0.456, and 0.527 in patients with an ileal, ileocolonic, and colonic disease location, respectively. Surgery for ileal lesions was less predictable than surgery for ileocolonic or colonic lesions during follow-up. CONCLUSIONS: CRP is less useful as a disease activity marker in patients with ileal CD than those with ileocolonic or colonic CD. |
format | Online Article Text |
id | pubmed-4282861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Gut and Liver |
record_format | MEDLINE/PubMed |
spelling | pubmed-42828612015-01-09 Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease Yang, Dong-Hoon Yang, Suk-Kyun Park, Sang Hyoung Lee, Ho-Su Boo, Sun-Jin Park, Jae-Ho Na, Soo Young Jung, Kee Wook Kim, Kyung-Jo Ye, Byong Duk Byeon, Jeong-Sik Myung, Seung-Jae Kim, Jin-Ho Gut Liver Original Article BACKGROUND/AIMS: C-reactive protein (CRP) is a serologic activity marker in Crohn’s disease (CD), but it may be less useful in evaluating CD activity in ileal CD patients. We aimed to investigate the usefulness of CRP as a disease activity marker in CD according to disease location. METHODS: Korean CD patients in a single hospital were evaluated. Factors associated with elevated CRP concentration at the time of diagnosis of CD and the association between the physician’s prediction regarding upcoming surgery and the sites of the lesions directly related to surgery were analyzed. RESULTS: Of 435 CD patients, 25.7%, 6.9%, and 67.4% had ileal, colonic, and ileocolonic CD, respectively. Multivariate analysis revealed that an elevated erythrocyte sedimentation rate, reduced serum albumin, CD activity index (CDAI) >220, and ileocolonic/colonic location were associated with an elevated CRP level and that the CRP level was significantly correlated with the CDAI in all CD patients (γ=0.466, p<0.01). However, the correlation coefficient was dependent on the location, with values of 0.395, 0.456, and 0.527 in patients with an ileal, ileocolonic, and colonic disease location, respectively. Surgery for ileal lesions was less predictable than surgery for ileocolonic or colonic lesions during follow-up. CONCLUSIONS: CRP is less useful as a disease activity marker in patients with ileal CD than those with ileocolonic or colonic CD. Gut and Liver 2015-01 2014-04-23 /pmc/articles/PMC4282861/ /pubmed/25170056 http://dx.doi.org/10.5009/gnl13424 Text en Copyright © 2015 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yang, Dong-Hoon Yang, Suk-Kyun Park, Sang Hyoung Lee, Ho-Su Boo, Sun-Jin Park, Jae-Ho Na, Soo Young Jung, Kee Wook Kim, Kyung-Jo Ye, Byong Duk Byeon, Jeong-Sik Myung, Seung-Jae Kim, Jin-Ho Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease |
title | Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease |
title_full | Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease |
title_fullStr | Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease |
title_full_unstemmed | Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease |
title_short | Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn’s Disease according to the Location of Disease |
title_sort | usefulness of c-reactive protein as a disease activity marker in crohn’s disease according to the location of disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282861/ https://www.ncbi.nlm.nih.gov/pubmed/25170056 http://dx.doi.org/10.5009/gnl13424 |
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