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A Phase I Study of High-Dose Calcitriol in Combination with Temozolomide for Patients with Metastatic Melanoma

Background: Temozolomide is efficacious as an oral alternative for patients with metastatic melanoma (MM). Calcitriol has anti-proliferative properties and vitamin D receptor (VDR) polymorphisms are associated with alterations in melanoma susceptibility and progression. Methods: Tem 150 mg/m(2) was...

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Detalles Bibliográficos
Autores principales: Pettijohn, Erin, Martone, Brenda, Rademaker, Alfred, Kuzel, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282882/
https://www.ncbi.nlm.nih.gov/pubmed/25563456
http://dx.doi.org/10.3390/jpm4040448