Functional normalization of 450k methylation array data improves replication in large cancer studies

We propose an extension to quantile normalization that removes unwanted technical variation using control probes. We adapt our algorithm, functional normalization, to the Illumina 450k methylation array and address the open problem of normalizing methylation data with global epigenetic changes, such...

Descripción completa

Detalles Bibliográficos
Autores principales: Fortin, Jean-Philippe, Labbe, Aurélie, Lemire, Mathieu, Zanke, Brent W, Hudson, Thomas J, Fertig, Elana J, Greenwood, Celia MT, Hansen, Kasper D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283580/
https://www.ncbi.nlm.nih.gov/pubmed/25599564
http://dx.doi.org/10.1186/s13059-014-0503-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283580/
https://www.ncbi.nlm.nih.gov/pubmed/25599564
http://dx.doi.org/10.1186/s13059-014-0503-2

Ejemplares similares