Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn Model

Although advantages of physiologically based pharmacokinetic models (PBPK) are now well established, PBPK models that are linked to pharmacodynamic (PD) models to predict pharmacokinetics (PK), PD, and efficacy of monoclonal antibodies (mAbs) in humans are uncommon. The aim of this study was to deve...

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Detalles Bibliográficos
Autores principales: Chetty, Manoranjenni, Li, Linzhong, Rose, Rachel, Machavaram, Krishna, Jamei, Masoud, Rostami-Hodjegan, Amin, Gardner, Iain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283607/
https://www.ncbi.nlm.nih.gov/pubmed/25601866
http://dx.doi.org/10.3389/fimmu.2014.00670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283607/
https://www.ncbi.nlm.nih.gov/pubmed/25601866
http://dx.doi.org/10.3389/fimmu.2014.00670

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