Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain

OBJECTIVES: Blockade of transient receptor potential vanilloid 1 (TRPV1) with systemic antagonists attenuates osteoarthritis (OA) pain behaviour in rat models, but on-target-mediated hyperthermia has halted clinical trials. The present study investigated the potential for targeting TRPV1 receptors w...

Descripción completa

Detalles Bibliográficos
Autores principales: Kelly, S, Chapman, R J, Woodhams, S, Sagar, D R, Turner, J, Burston, J J, Bullock, C, Paton, K, Huang, J, Wong, A, McWilliams, D F, Okine, B N, Barrett, D A, Hathway, G J, Walsh, D A, Chapman, V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283626/
https://www.ncbi.nlm.nih.gov/pubmed/24152419
http://dx.doi.org/10.1136/annrheumdis-2013-203413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283626/
https://www.ncbi.nlm.nih.gov/pubmed/24152419
http://dx.doi.org/10.1136/annrheumdis-2013-203413

Ejemplares similares