Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes

Impaired angiogenesis and endothelial dysfunction in type 2 diabetes constitute dominant risk factors for non-healing wounds and most forms of cardiovascular disease. We propose that diabetes shifts the ‘angiogenic balance’ in favor of an excessive anti-angiogenic phenotype. Herein, we report that d...

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Detalles Bibliográficos
Autores principales: Bitar, Milad S., Al-Mulla, Fahd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283651/
https://www.ncbi.nlm.nih.gov/pubmed/25381014
http://dx.doi.org/10.1242/dmm.017145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283651/
https://www.ncbi.nlm.nih.gov/pubmed/25381014
http://dx.doi.org/10.1242/dmm.017145

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