Characterization of mutations in the PAS domain of the EvgS sensor kinase selected by laboratory evolution for acid resistance in Escherichia coli

Laboratory-based evolution and whole-genome sequencing can link genotype and phenotype. We used evolution of acid resistance in exponential phase Escherichia coli to study resistance to a lethal stress. Iterative selection at pH 2.5 generated five populations that were resistant to low pH in early e...

Descripción completa

Detalles Bibliográficos
Autores principales: Johnson, Matthew D, Bell, James, Clarke, Kim, Chandler, Rachel, Pathak, Prachi, Xia, Yandong, Marshall, Robert L, Weinstock, George M, Loman, Nicholas J, Winn, Peter J, Lund, Peter A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283999/
https://www.ncbi.nlm.nih.gov/pubmed/24995530
http://dx.doi.org/10.1111/mmi.12704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283999/
https://www.ncbi.nlm.nih.gov/pubmed/24995530
http://dx.doi.org/10.1111/mmi.12704

Ejemplares similares