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Characterization of mutations in the PAS domain of the EvgS sensor kinase selected by laboratory evolution for acid resistance in Escherichia coli

Laboratory-based evolution and whole-genome sequencing can link genotype and phenotype. We used evolution of acid resistance in exponential phase Escherichia coli to study resistance to a lethal stress. Iterative selection at pH 2.5 generated five populations that were resistant to low pH in early e...

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Detalles Bibliográficos
Autores principales:	Johnson, Matthew D, Bell, James, Clarke, Kim, Chandler, Rachel, Pathak, Prachi, Xia, Yandong, Marshall, Robert L, Weinstock, George M, Loman, Nicholas J, Winn, Peter J, Lund, Peter A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283999/ https://www.ncbi.nlm.nih.gov/pubmed/24995530 http://dx.doi.org/10.1111/mmi.12704

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