Sirtuin 1 activator SRT2104 protects Huntington's disease mice
Sirtuin 1 is a nicotinamide adenine dinucleotide-dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284130/ https://www.ncbi.nlm.nih.gov/pubmed/25574479 http://dx.doi.org/10.1002/acn3.135 |
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author | Jiang, Mali Zheng, Jennifer Peng, Qi Hou, Zhipeng Zhang, Jiangyang Mori, Susumu Ellis, James L Vlasuk, George P Fries, Harvey Suri, Vipin Duan, Wenzhen |
author_facet | Jiang, Mali Zheng, Jennifer Peng, Qi Hou, Zhipeng Zhang, Jiangyang Mori, Susumu Ellis, James L Vlasuk, George P Fries, Harvey Suri, Vipin Duan, Wenzhen |
author_sort | Jiang, Mali |
collection | PubMed |
description | Sirtuin 1 is a nicotinamide adenine dinucleotide-dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin 1 plays a neuroprotective role in mouse models of Huntington's disease. In this study, we report that SRT2104, a small molecule Sirtuin 1 activator, penetrated the blood–brain barrier, attenuated brain atrophy, improved motor function, and extended survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1. |
format | Online Article Text |
id | pubmed-4284130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42841302015-01-08 Sirtuin 1 activator SRT2104 protects Huntington's disease mice Jiang, Mali Zheng, Jennifer Peng, Qi Hou, Zhipeng Zhang, Jiangyang Mori, Susumu Ellis, James L Vlasuk, George P Fries, Harvey Suri, Vipin Duan, Wenzhen Ann Clin Transl Neurol Brief Communications Sirtuin 1 is a nicotinamide adenine dinucleotide-dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin 1 plays a neuroprotective role in mouse models of Huntington's disease. In this study, we report that SRT2104, a small molecule Sirtuin 1 activator, penetrated the blood–brain barrier, attenuated brain atrophy, improved motor function, and extended survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1. Blackwell Publishing Ltd 2014-12 2014-10-31 /pmc/articles/PMC4284130/ /pubmed/25574479 http://dx.doi.org/10.1002/acn3.135 Text en © 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Brief Communications Jiang, Mali Zheng, Jennifer Peng, Qi Hou, Zhipeng Zhang, Jiangyang Mori, Susumu Ellis, James L Vlasuk, George P Fries, Harvey Suri, Vipin Duan, Wenzhen Sirtuin 1 activator SRT2104 protects Huntington's disease mice |
title | Sirtuin 1 activator SRT2104 protects Huntington's disease mice |
title_full | Sirtuin 1 activator SRT2104 protects Huntington's disease mice |
title_fullStr | Sirtuin 1 activator SRT2104 protects Huntington's disease mice |
title_full_unstemmed | Sirtuin 1 activator SRT2104 protects Huntington's disease mice |
title_short | Sirtuin 1 activator SRT2104 protects Huntington's disease mice |
title_sort | sirtuin 1 activator srt2104 protects huntington's disease mice |
topic | Brief Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284130/ https://www.ncbi.nlm.nih.gov/pubmed/25574479 http://dx.doi.org/10.1002/acn3.135 |
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