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Absence of Dap12 and the αvβ3 integrin causes severe osteopetrosis
In vitro, ligand occupancy of αvβ3 integrin induces phosphorylation of Dap12, which is essential for osteoclast function. Like mice deleted of only αvβ3, Dap12(−/−) mice exhibited a slight increase in bone mass, but Dap12(−/−) mice, lacking another ITAM protein, FcRγ, were severely osteopetrotic. Th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284236/ https://www.ncbi.nlm.nih.gov/pubmed/25547154 http://dx.doi.org/10.1083/jcb.201410123 |