Interaction of methotrexate, an anticancer agent, with copper(II) ions: coordination pattern, DNA-cleaving properties and cytotoxic studies

The acid–base properties and the Cu(II) binding processes of methotrexate (MTX) were characterized by selected spectroscopic techniques and potentiometric measurements. The pH titration data showed that MTX behaves as a triprotic ligand. The deprotonation constants were determined for α-COOH and γ-C...

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Detalles Bibliográficos
Autores principales: Nagaj, Justyna, Kołkowska, Paulina, Bykowska, Aleksandra, Komarnicka, Urszula K., Kyzioł, Agnieszka, Jeżowska-Bojczuk, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284383/
https://www.ncbi.nlm.nih.gov/pubmed/25589824
http://dx.doi.org/10.1007/s00044-014-1074-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284383/
https://www.ncbi.nlm.nih.gov/pubmed/25589824
http://dx.doi.org/10.1007/s00044-014-1074-1

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