Quantitative Measurement of the Target-Mediated Internalization Kinetics of Biopharmaceuticals

PURPOSE: Measurement of internalization of biopharmaceuticals targeting cell surface proteins can greatly facilitate drug development. The objective of this study was to develop a reliable method for determination of internalization rate constant (k(int)) and to demonstrate its utility. METHODS: Thi...

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Detalles Bibliográficos
Autores principales: Vainshtein, Inna, Roskos, Lorin K., Cheng, Jackie, Sleeman, Matthew A., Wang, Bing, Liang, Meina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284384/
https://www.ncbi.nlm.nih.gov/pubmed/25208874
http://dx.doi.org/10.1007/s11095-014-1462-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284384/
https://www.ncbi.nlm.nih.gov/pubmed/25208874
http://dx.doi.org/10.1007/s11095-014-1462-8

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