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Quantitative Measurement of the Target-Mediated Internalization Kinetics of Biopharmaceuticals
PURPOSE: Measurement of internalization of biopharmaceuticals targeting cell surface proteins can greatly facilitate drug development. The objective of this study was to develop a reliable method for determination of internalization rate constant (k(int)) and to demonstrate its utility. METHODS: Thi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284384/ https://www.ncbi.nlm.nih.gov/pubmed/25208874 http://dx.doi.org/10.1007/s11095-014-1462-8 |