A Biomimetic Strategy to Access the Silybins: Total Synthesis of (−)-Isosilybin A

[Image: see text] We report the first asymmetric, total synthesis of (−)-isosilybin A. A late-stage catalytic biomimetic cyclization of a highly functionalized chalcone is employed to form the characteristic benzopyranone ring. A robust and flexible approach to this chalcone provides an entry to the...

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Detalles Bibliográficos
Autores principales: McDonald, Benjamin R., Nibbs, Antoinette E., Scheidt, Karl A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284651/
https://www.ncbi.nlm.nih.gov/pubmed/25517432
http://dx.doi.org/10.1021/ol503303w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284651/
https://www.ncbi.nlm.nih.gov/pubmed/25517432
http://dx.doi.org/10.1021/ol503303w

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