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A Biomimetic Strategy to Access the Silybins: Total Synthesis of (−)-Isosilybin A
[Image: see text] We report the first asymmetric, total synthesis of (−)-isosilybin A. A late-stage catalytic biomimetic cyclization of a highly functionalized chalcone is employed to form the characteristic benzopyranone ring. A robust and flexible approach to this chalcone provides an entry to the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284651/ https://www.ncbi.nlm.nih.gov/pubmed/25517432 http://dx.doi.org/10.1021/ol503303w |