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The Importance of Polarity in the Evolution of the K(+) Binding Site of Pyruvate Kinase
In a previous phylogenetic study of the family of pyruvate kinase, we found one cluster with Glu117 and another with Lys117. Those sequences with Glu117 have Thr113 and are K(+)-dependent, whereas those with Lys117 have Leu113 and are K(+)-independent. The carbonyl oxygen of Thr113 is one of the res...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284704/ https://www.ncbi.nlm.nih.gov/pubmed/25474090 http://dx.doi.org/10.3390/ijms151222214 |