Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels

African trypanosomes are an excellent system for quantitative modelling of post-transcriptional mRNA control. Transcription is constitutive and polycistronic; individual mRNAs are excised by trans splicing and polyadenylation. We here measure mRNA decay kinetics in two life cycle stages, bloodstream...

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Detalles Bibliográficos
Autores principales: Fadda, Abeer, Ryten, Mark, Droll, Dorothea, Rojas, Federico, Färber, Valentin, Haanstra, Jurgen R, Merce, Clemetine, Bakker, Barbara M, Matthews, Keith, Clayton, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285177/
https://www.ncbi.nlm.nih.gov/pubmed/25145465
http://dx.doi.org/10.1111/mmi.12764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285177/
https://www.ncbi.nlm.nih.gov/pubmed/25145465
http://dx.doi.org/10.1111/mmi.12764

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