Cargando…

STAT3 paradoxically stimulates β-catenin expression but inhibits β-catenin function

Wnt signalling and the signal transducer and activator of transcription 3 (STAT3) are oncogenic signalling pathways which are deregulated in colorectal cancer (CRC). Here we investigated the interaction of these two pathways. Firstly, we investigated biochemical interaction by inhibiting STAT3 and β...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ibrahem, Salih, Al-Ghamdi, Saleh, Baloch, Kanwal, Muhammad, Belal, Fadhil, Wakkas, Jackson, Darryl, Nateri, Abdolrahman S, Ilyas, Mohammad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285465/ https://www.ncbi.nlm.nih.gov/pubmed/25348333 http://dx.doi.org/10.1111/iep.12102

Ejemplares similares

Cten Is Targeted by Kras Signalling to Regulate Cell Motility in the Colon and Pancreas
por: Al-Ghamdi, Saleh, et al.
Publicado: (2011)

Increased FLYWCH1 Expression is Negatively Correlated with Wnt/β-catenin Target Gene Expression in Acute Myeloid Leukemia Cells
por: Almars, Amany, et al.
Publicado: (2019)

Stimulation of HERG Channel Activity by β-catenin
por: Munoz, Carlos, et al.
Publicado: (2012)

Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
por: Lin, Chung-Ming, et al.
Publicado: (2017)

Inhibition of β-Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear β-Catenin/TCF-1 complex: Critical role of STAT-3
por: Pramanik, Kartick C., et al.
Publicado: (2015)

β‐Catenin Accumulation and Mutation of Exon 3 of the β‐Catenin Gene in Hepatocellular Carcinoma
por: Kondo, Yutaka, et al.
Publicado: (1999)

Out with the active β-catenin
por: LeBrasseur, Nicole
Publicado: (2005)

Another job for β-catenin
por: Tuma, Rabiya S.
Publicado: (2005)

Killing the β-catenin messenger
por: Leslie, Mitch
Publicado: (2009)

β-catenin in epithelial tumorigenesis
por: Lu, Tsai-Ling, et al.
Publicado: (2015)

Phosphorylation Reduces the Mechanical Stability of the α‐Catenin/ β‐Catenin Complex
por: Le, Shimin, et al.
Publicado: (2019)

Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway
por: Jeong, Woo-Jeong, et al.
Publicado: (2018)

Transcriptional impairment of β-catenin/E-cadherin complex is not associated with β-catenin mutations in colorectal carcinomas
por: Garinis, G A, et al.
Publicado: (2003)

MicroRNA-200a suppresses the Wnt/β-catenin signaling pathway by interacting with β-catenin
por: SU, JUAN, et al.
Publicado: (2011)

NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells
por: Wu, Nan, et al.
Publicado: (2018)

WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID
por: Sato, Atsushi, et al.
Publicado: (2020)

KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer
por: Yao, Hanhui, et al.
Publicado: (2022)

Rac1 augments Wnt signaling by stimulating β-catenin–lymphoid enhancer factor-1 complex assembly independent of β-catenin nuclear import
por: Jamieson, Cara, et al.
Publicado: (2015)

β-Catenin is Required for Memory Consolidation
por: Maguschak, Kimberly A., et al.
Publicado: (2008)

β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis
por: Cobas, Monica, et al.
Publicado: (2004)

β-Catenin gets an honorable discharge
por: Short, Ben
Publicado: (2010)

β-catenin activated hepatocellular adenoma
por: Chu, Hyun Hee, et al.
Publicado: (2013)

WNKs in Wnt/β-catenin signaling
por: Serysheva, Ekatherina, et al.
Publicado: (2014)

β catenin in health: A review
por: Prakash, Sharada, et al.
Publicado: (2015)

Wnt/β-Catenin Signaling and Obesity
por: Chen, Na, et al.
Publicado: (2018)

β-Catenin signaling in hepatocellular carcinoma
por: Xu, Chuanrui, et al.
Publicado: (2022)

The role of β-catenin in cardiac diseases
por: Ni, Beibei, et al.
Publicado: (2023)

p120-catenin and β-catenin differentially regulate cadherin adhesive function
por: Oas, Rebecca G., et al.
Publicado: (2013)

β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells
por: Zhao, Xin, et al.
Publicado: (2020)

Aberrant nuclear localization of β-catenin without genetic alterations in β-catenin or Axin genes in esophageal cancer
por: Kudo, Junzo, et al.
Publicado: (2007)

Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin
por: Chinison, Jessica, et al.
Publicado: (2016)

Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo
por: Uehara, Yoshihiko, et al.
Publicado: (2014)

The stem-like Stat3-responsive cells of zebrafish intestine are Wnt/β-catenin dependent
por: Peron, Margherita, et al.
Publicado: (2020)

Wnt/β-Catenin Signaling Modulates Human Airway Sensitization Induced by β(2)-Adrenoceptor Stimulation
por: Faisy, Christophe, et al.
Publicado: (2014)

Novel β-carbolines inhibit Wnt/β-catenin signaling
por: Kong, L, et al.
Publicado: (2015)

β-catenin is overexpressed in hepatic fibrosis and blockage of Wnt/β-catenin signaling inhibits hepatic stellate cell activation
por: GE, WEN-SONG, et al.
Publicado: (2014)

Comprehensive analysis of β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling
por: Herbst, Andreas, et al.
Publicado: (2014)

Imaging features of β-catenin-activated hepatocellular adenoma with weak β-catenin activation: A rare case report
por: Minamiguchi, Kiyoyuki, et al.
Publicado: (2022)

β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer
por: Wu, Yuting, et al.
Publicado: (2023)

Kaiso Interacts with p120-Catenin to Regulate β-Catenin Expression at the Transcriptional Level
por: Liu, Yang, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_l0380lkj0absbugd49flv9eag5