A novel systemically administered toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models

Although topical TLR7 therapies such as imiquimod have proved successful in the treatment of dermatological malignancy, systemic delivery may be required for optimal immunotherapy of nondermatological tumors. We report that intravenous delivery of the novel small molecule TLR7 agonist, DSR-6434, lea...

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Detalles Bibliográficos
Autores principales: Adlard, Amy L, Dovedi, Simon J, Telfer, Brian A, Koga-Yamakawa, Erina, Pollard, Charlotte, Honeychurch, Jamie, Illidge, Timothy M, Murata, Masashi, Robinson, David T, Jewsbury, Philip J, Wilkinson, Robert W, Stratford, Ian J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286010/
https://www.ncbi.nlm.nih.gov/pubmed/24390981
http://dx.doi.org/10.1002/ijc.28711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286010/
https://www.ncbi.nlm.nih.gov/pubmed/24390981
http://dx.doi.org/10.1002/ijc.28711

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