A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery

A wider application of siRNA- and miRNA- based therapeutics is restricted by the currently available delivery systems. We have designed a new type of small molecule carrier (SMoC) system for siRNA modeled to interact with cell surface proteoglycans. This bifurcated SMoC has similar affinity for the...

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Detalles Bibliográficos
Autores principales: Gooding, Matt, Adigbli, Derick, Edith Chan, A W, Melander, Roberta J, MacRobert, Alexander J, Selwood, David L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286013/
https://www.ncbi.nlm.nih.gov/pubmed/24472581
http://dx.doi.org/10.1111/cbdd.12295
Descripción
Sumario:A wider application of siRNA- and miRNA- based therapeutics is restricted by the currently available delivery systems. We have designed a new type of small molecule carrier (SMoC) system for siRNA modeled to interact with cell surface proteoglycans. This bifurcated SMoC has similar affinity for the model proteoglycan heparin to an equivalent polyarginine peptide and exhibits significant mRNA knockdown of protein levels comparable to lipofectamine and the previously reported linear SMoC.

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