A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery

A wider application of siRNA- and miRNA- based therapeutics is restricted by the currently available delivery systems. We have designed a new type of small molecule carrier (SMoC) system for siRNA modeled to interact with cell surface proteoglycans. This bifurcated SMoC has similar affinity for the...

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Detalles Bibliográficos
Autores principales: Gooding, Matt, Adigbli, Derick, Edith Chan, A W, Melander, Roberta J, MacRobert, Alexander J, Selwood, David L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286013/
https://www.ncbi.nlm.nih.gov/pubmed/24472581
http://dx.doi.org/10.1111/cbdd.12295
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author Gooding, Matt
Adigbli, Derick
Edith Chan, A W
Melander, Roberta J
MacRobert, Alexander J
Selwood, David L
author_facet Gooding, Matt
Adigbli, Derick
Edith Chan, A W
Melander, Roberta J
MacRobert, Alexander J
Selwood, David L
author_sort Gooding, Matt
collection PubMed
description A wider application of siRNA- and miRNA- based therapeutics is restricted by the currently available delivery systems. We have designed a new type of small molecule carrier (SMoC) system for siRNA modeled to interact with cell surface proteoglycans. This bifurcated SMoC has similar affinity for the model proteoglycan heparin to an equivalent polyarginine peptide and exhibits significant mRNA knockdown of protein levels comparable to lipofectamine and the previously reported linear SMoC.
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spelling pubmed-42860132015-01-14 A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery Gooding, Matt Adigbli, Derick Edith Chan, A W Melander, Roberta J MacRobert, Alexander J Selwood, David L Chem Biol Drug Des Research Articles A wider application of siRNA- and miRNA- based therapeutics is restricted by the currently available delivery systems. We have designed a new type of small molecule carrier (SMoC) system for siRNA modeled to interact with cell surface proteoglycans. This bifurcated SMoC has similar affinity for the model proteoglycan heparin to an equivalent polyarginine peptide and exhibits significant mRNA knockdown of protein levels comparable to lipofectamine and the previously reported linear SMoC. BlackWell Publishing Ltd 2014-07 2014-05-13 /pmc/articles/PMC4286013/ /pubmed/24472581 http://dx.doi.org/10.1111/cbdd.12295 Text en © 2014 The Authors. Chemical Biology & Drug Design Published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Gooding, Matt
Adigbli, Derick
Edith Chan, A W
Melander, Roberta J
MacRobert, Alexander J
Selwood, David L
A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery
title A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery
title_full A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery
title_fullStr A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery
title_full_unstemmed A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery
title_short A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery
title_sort bifurcated proteoglycan binding small molecule carrier for sirna delivery
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286013/
https://www.ncbi.nlm.nih.gov/pubmed/24472581
http://dx.doi.org/10.1111/cbdd.12295
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