The Sirt1 activator SRT3025 provides atheroprotection in Apoe(−/−) mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

AIMS: The deacetylase sirtuin 1 (Sirt1) exerts beneficial effects on lipid metabolism, but its roles in plasma LDL-cholesterol regulation and atherosclerosis are controversial. Thus, we applied the pharmacological Sirt1 activator SRT3025 in a mouse model of atherosclerosis and in hepatocyte culture....

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Detalles Bibliográficos
Autores principales: Miranda, Melroy X., van Tits, Lambertus J., Lohmann, Christine, Arsiwala, Tasneem, Winnik, Stephan, Tailleux, Anne, Stein, Sokrates, Gomes, Ana P., Suri, Vipin, Ellis, James L., Lutz, Thomas A., Hottiger, Michael O., Sinclair, David A., Auwerx, Johan, Schoonjans, Kristina, Staels, Bart, Lüscher, Thomas F., Matter, Christian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
FASTTrack Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286317/
https://www.ncbi.nlm.nih.gov/pubmed/24603306
http://dx.doi.org/10.1093/eurheartj/ehu095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286317/
https://www.ncbi.nlm.nih.gov/pubmed/24603306
http://dx.doi.org/10.1093/eurheartj/ehu095

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