The Sirt1 activator SRT3025 provides atheroprotection in Apoe(−/−) mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
AIMS: The deacetylase sirtuin 1 (Sirt1) exerts beneficial effects on lipid metabolism, but its roles in plasma LDL-cholesterol regulation and atherosclerosis are controversial. Thus, we applied the pharmacological Sirt1 activator SRT3025 in a mouse model of atherosclerosis and in hepatocyte culture....
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286317/ https://www.ncbi.nlm.nih.gov/pubmed/24603306 http://dx.doi.org/10.1093/eurheartj/ehu095 |