A common functional consequence of tumor-derived mutations within c-MYC

The relevance of changes to the coding sequence of the c-MYC oncogene to malignancy is controversial. Overexpression of a pristine form of MYC is observed in many cancers and is sufficient to drive tumorigenesis in most contexts. Yet missense changes to MYC are found in ~50% of Burkitt’s lymphomas,...

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Detalles Bibliográficos
Autores principales: Chakraborty, Abhishek A., Scuoppo, Claudio, Dey, Soumyadeep, Thomas, Lance R., Lorey, Shelly L., Lowe, Scott W., Tansey, William. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286529/
https://www.ncbi.nlm.nih.gov/pubmed/24998853
http://dx.doi.org/10.1038/onc.2014.186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286529/
https://www.ncbi.nlm.nih.gov/pubmed/24998853
http://dx.doi.org/10.1038/onc.2014.186

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