A Framework for Inferring Fitness Landscapes of Patient-Derived Viruses Using Quasispecies Theory

Fitness is a central quantity in evolutionary models of viruses. However, it remains difficult to determine viral fitness experimentally, and existing in vitro assays can be poor predictors of in vivo fitness of viral populations within their hosts. Next-generation sequencing can nowadays provide sn...

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Detalles Bibliográficos
Autores principales: Seifert, David, Di Giallonardo, Francesca, Metzner, Karin J., Günthard, Huldrych F., Beerenwinkel, Niko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2015
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286684/
https://www.ncbi.nlm.nih.gov/pubmed/25406469
http://dx.doi.org/10.1534/genetics.114.172312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286684/
https://www.ncbi.nlm.nih.gov/pubmed/25406469
http://dx.doi.org/10.1534/genetics.114.172312

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