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A Framework for Inferring Fitness Landscapes of Patient-Derived Viruses Using Quasispecies Theory
Fitness is a central quantity in evolutionary models of viruses. However, it remains difficult to determine viral fitness experimentally, and existing in vitro assays can be poor predictors of in vivo fitness of viral populations within their hosts. Next-generation sequencing can nowadays provide sn...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Genetics Society of America
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286684/ https://www.ncbi.nlm.nih.gov/pubmed/25406469 http://dx.doi.org/10.1534/genetics.114.172312 |