Characterization and immunological activity of different forms of recombinant secreted Hc of botulinum neurotoxin serotype B products expressed in yeast

The recombinant Hc proteins of botulinum neurotoxins and tetanus toxin are exclusively produced by intracellular heterologous expression in Pichia pastoris for use in subunit vaccines; the same Hc proteins produced by secreted heterologous expression are hyper-glycosylated and immunologically inert....

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Detalles Bibliográficos
Autores principales: Liu, Bo, Shi, DanYang, Chang, ShaoHong, Gong, Xin, Yu, YunZhou, Sun, ZhiWei, Wu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286741/
https://www.ncbi.nlm.nih.gov/pubmed/25567004
http://dx.doi.org/10.1038/srep07678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286741/
https://www.ncbi.nlm.nih.gov/pubmed/25567004
http://dx.doi.org/10.1038/srep07678

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