Meiotic interstrand DNA damage escapes paternal repair and causes chromosomal aberrations in the zygote by maternal misrepair

De novo point mutations and chromosomal structural aberrations (CSA) detected in offspring of unaffected parents show a preferential paternal origin with higher risk for older fathers. Studies in rodents suggest that heritable mutations transmitted from the father can arise from either paternal or m...

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Detalles Bibliográficos
Autores principales: Marchetti, Francesco, Bishop, Jack, Gingerich, John, Wyrobek, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286742/
https://www.ncbi.nlm.nih.gov/pubmed/25567288
http://dx.doi.org/10.1038/srep07689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286742/
https://www.ncbi.nlm.nih.gov/pubmed/25567288
http://dx.doi.org/10.1038/srep07689

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