Proinflammatory TLR signaling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages

Signal transduction from toll-like receptors (TLRs) is important for innate immunity against infections, but deregulated TLR signaling contributes to inflammatory disorders. Here we show that myeloid cell-specific ablation of TRAF2 greatly promotes TLR-stimulated proinflammatory cytokine expression...

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Detalles Bibliográficos
Autores principales: Jin, Jin, Xiao, Yichuan, Hu, Hongbo, Zou, Qiang, Li, Yanchuan, Gao, Yanpan, Ge, Wei, Cheng, Xuhong, Sun, Shao-Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286812/
https://www.ncbi.nlm.nih.gov/pubmed/25565375
http://dx.doi.org/10.1038/ncomms6930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286812/
https://www.ncbi.nlm.nih.gov/pubmed/25565375
http://dx.doi.org/10.1038/ncomms6930

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