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Integrative Analysis of DNA Methylation and Gene Expression Data Identifies EPAS1 as a Key Regulator of COPD
Chronic Obstructive Pulmonary Disease (COPD) is a complex disease. Genetic, epigenetic, and environmental factors are known to contribute to COPD risk and disease progression. Therefore we developed a systematic approach to identify key regulators of COPD that integrates genome-wide DNA methylation,...
Autores principales: | Yoo, Seungyeul, Takikawa, Sachiko, Geraghty, Patrick, Argmann, Carmen, Campbell, Joshua, Lin, Luan, Huang, Tao, Tu, Zhidong, Feronjy, Robert, Spira, Avrum, Schadt, Eric E., Powell, Charles A., Zhu, Jun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287352/ https://www.ncbi.nlm.nih.gov/pubmed/25569234 http://dx.doi.org/10.1371/journal.pgen.1004898 |
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