PRDM9 Drives Evolutionary Erosion of Hotspots in Mus musculus through Haplotype-Specific Initiation of Meiotic Recombination

Meiotic recombination generates new genetic variation and assures the proper segregation of chromosomes in gametes. PRDM9, a zinc finger protein with histone methyltransferase activity, initiates meiotic recombination by binding DNA at recombination hotspots and directing the position of DNA double-...

Descripción completa

Detalles Bibliográficos
Autores principales: Baker, Christopher L., Kajita, Shimpei, Walker, Michael, Saxl, Ruth L., Raghupathy, Narayanan, Choi, Kwangbom, Petkov, Petko M., Paigen, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287450/
https://www.ncbi.nlm.nih.gov/pubmed/25568937
http://dx.doi.org/10.1371/journal.pgen.1004916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287450/
https://www.ncbi.nlm.nih.gov/pubmed/25568937
http://dx.doi.org/10.1371/journal.pgen.1004916

Ejemplares similares