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PRDM9 Drives Evolutionary Erosion of Hotspots in Mus musculus through Haplotype-Specific Initiation of Meiotic Recombination

Meiotic recombination generates new genetic variation and assures the proper segregation of chromosomes in gametes. PRDM9, a zinc finger protein with histone methyltransferase activity, initiates meiotic recombination by binding DNA at recombination hotspots and directing the position of DNA double-...

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Detalles Bibliográficos
Autores principales:	Baker, Christopher L., Kajita, Shimpei, Walker, Michael, Saxl, Ruth L., Raghupathy, Narayanan, Choi, Kwangbom, Petkov, Petko M., Paigen, Kenneth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287450/ https://www.ncbi.nlm.nih.gov/pubmed/25568937 http://dx.doi.org/10.1371/journal.pgen.1004916

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