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Differential Reliance on Autophagy for Protection from HSV Encephalitis between Newborns and Adults
Newborns are more susceptible to severe disease from infection than adults, with maturation of immune responses implicated as a major factor. The type I interferon response delays mortality and limits viral replication in adult mice in a model of herpes simplex virus (HSV) encephalitis. We found tha...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287605/ https://www.ncbi.nlm.nih.gov/pubmed/25569138 http://dx.doi.org/10.1371/journal.ppat.1004580 |