The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer

Constitutive activation of canonical WNT-TCF signaling is implicated in multiple diseases, including intestine and lung cancers, but there are no WNT-TCF antagonists in clinical use. We have performed a repositioning screen for WNT-TCF response blockers aiming to recapitulate the genetic blockade af...

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Detalles Bibliográficos
Autores principales: Melotti, Alice, Mas, Christophe, Kuciak, Monika, Lorente-Trigos, Aiala, Borges, Isabel, Ruiz i Altaba, Ariel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287931/
https://www.ncbi.nlm.nih.gov/pubmed/25143352
http://dx.doi.org/10.15252/emmm.201404084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287931/
https://www.ncbi.nlm.nih.gov/pubmed/25143352
http://dx.doi.org/10.15252/emmm.201404084

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