CHIP, a carboxy terminus HSP-70 interacting protein, prevents cell death induced by endoplasmic reticulum stress in the central nervous system

Endoplasmic reticulum (ER) stress and protein misfolding are associated with various neurodegenerative diseases. ER stress activates unfolded protein response (UPR), an adaptative response. However, severe ER stress can induce cell death. Here we show that the E3 ubiquitin ligase and co-chaperone Ca...

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Detalles Bibliográficos
Autores principales: Cabral Miranda, Felipe, Adão-Novaes, Juliana, Hauswirth, William W., Linden, Rafael, Petrs-Silva, Hilda, Chiarini, Luciana B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288139/
https://www.ncbi.nlm.nih.gov/pubmed/25620910
http://dx.doi.org/10.3389/fncel.2014.00438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288139/
https://www.ncbi.nlm.nih.gov/pubmed/25620910
http://dx.doi.org/10.3389/fncel.2014.00438

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