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Flexibility and structural conservation in a c-KIT G-quadruplex

A quadruplex sequence from the promoter region of the c-KIT gene forms a stable quadruplex, as characterized by crystallographic and NMR methods. Two new crystal structures are reported here, together with molecular dynamics simulation studies on these quadruplex crystal structures and an NMR struct...

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Detalles Bibliográficos
Autores principales: Wei, Dengguo, Husby, Jarmila, Neidle, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288176/
https://www.ncbi.nlm.nih.gov/pubmed/25452341
http://dx.doi.org/10.1093/nar/gku1282