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A new heavy lanthanide-dependent DNAzyme displaying strong metal cooperativity and unrescuable phosphorothioate effect

In vitro selection of RNA-cleaving DNAzymes was performed using three heavy lanthanide ions (Ln(3+)): Ho(3+), Er(3+) and Tm(3+). The resulting sequences were aligned together and about half of the library contained a new family of DNAzyme. These DNAzymes have a simple loop structure, and they are ac...

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Detalles Bibliográficos
Autores principales: Huang, Po-Jung Jimmy, Vazin, Mahsa, Matuszek, Żaneta, Liu, Juewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288186/
https://www.ncbi.nlm.nih.gov/pubmed/25488814
http://dx.doi.org/10.1093/nar/gku1296