Insights into the species-specific TLR4 signaling mechanism in response to Rhodobacter sphaeroides lipid A detection

TLR4 in complex with MD2 senses the presence of lipid A (LA) and initiates a signaling cascade that curb the infection. This complex is evolutionarily conserved and can initiate the immune system in response to a variety of LAs. In this study, molecular dynamics simulation (25 ns) was performed to e...

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Detalles Bibliográficos
Autores principales: Anwar, Muhammad Ayaz, Panneerselvam, Suresh, Shah, Masaud, Choi, Sangdun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288214/
https://www.ncbi.nlm.nih.gov/pubmed/25563849
http://dx.doi.org/10.1038/srep07657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288214/
https://www.ncbi.nlm.nih.gov/pubmed/25563849
http://dx.doi.org/10.1038/srep07657

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