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Insights into the species-specific TLR4 signaling mechanism in response to Rhodobacter sphaeroides lipid A detection
TLR4 in complex with MD2 senses the presence of lipid A (LA) and initiates a signaling cascade that curb the infection. This complex is evolutionarily conserved and can initiate the immune system in response to a variety of LAs. In this study, molecular dynamics simulation (25 ns) was performed to e...
Autores principales: | Anwar, Muhammad Ayaz, Panneerselvam, Suresh, Shah, Masaud, Choi, Sangdun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288214/ https://www.ncbi.nlm.nih.gov/pubmed/25563849 http://dx.doi.org/10.1038/srep07657 |
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