HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis

Histone deacetylase inhibitors (HDACi) are agents capable of inducing growth arrest and apoptosis in different tumour cell types. Previously, we reported a series of novel HDACi obtained by hybridizing SAHA or oxamflatin with 1,4-benzodiazepines. Some of these hybrids proved effective against haemat...

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Detalles Bibliográficos
Autores principales: Balliu, Manjola, Guandalini, Luca, Romanelli, Maria Novella, D'Amico, Massimo, Paoletti, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288358/
https://www.ncbi.nlm.nih.gov/pubmed/25376115
http://dx.doi.org/10.1111/jcmm.12345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288358/
https://www.ncbi.nlm.nih.gov/pubmed/25376115
http://dx.doi.org/10.1111/jcmm.12345

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