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HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis
Histone deacetylase inhibitors (HDACi) are agents capable of inducing growth arrest and apoptosis in different tumour cell types. Previously, we reported a series of novel HDACi obtained by hybridizing SAHA or oxamflatin with 1,4-benzodiazepines. Some of these hybrids proved effective against haemat...
Autores principales: | Balliu, Manjola, Guandalini, Luca, Romanelli, Maria Novella, D'Amico, Massimo, Paoletti, Francesco |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288358/ https://www.ncbi.nlm.nih.gov/pubmed/25376115 http://dx.doi.org/10.1111/jcmm.12345 |
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