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ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non-alcoholic fatty liver disease
ASPP2 is a pro-apoptotic member of the p53 binding protein family. ASPP2 has been shown to inhibit autophagy, which maintains energy balance in nutritional deprivation. We attempted to identify the role of ASPP2 in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In a NAFLD cell model,...
Autores principales: | Xie, Fang, Jia, Lin, Lin, Minghua, Shi, Ying, Yin, Jiming, Liu, Yin, Chen, Dexi, Meng, Qinghua |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288359/ https://www.ncbi.nlm.nih.gov/pubmed/25256142 http://dx.doi.org/10.1111/jcmm.12364 |
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