Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae

Bacterial biofilms are estimated to be associated with over 65 percent of all nosocomial infections. However, no therapeutics have been approved by the FDA which directly mediate biofilm formation or persistence. Herein we report oxazine 25 as a highly potent inhibitor, disperser and in the presence...

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Detalles Bibliográficos
Autores principales: Warner, Christopher J. A., Cheng, Andrew T., Yildiz, Fitnat H., Linington, Roger G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288701/
https://www.ncbi.nlm.nih.gov/pubmed/25479128
http://dx.doi.org/10.1039/c4cc07003h
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author Warner, Christopher J. A.
Cheng, Andrew T.
Yildiz, Fitnat H.
Linington, Roger G.
author_facet Warner, Christopher J. A.
Cheng, Andrew T.
Yildiz, Fitnat H.
Linington, Roger G.
author_sort Warner, Christopher J. A.
collection PubMed
description Bacterial biofilms are estimated to be associated with over 65 percent of all nosocomial infections. However, no therapeutics have been approved by the FDA which directly mediate biofilm formation or persistence. Herein we report oxazine 25 as a highly potent inhibitor, disperser and in the presence of the appropriate antibiotic eradicator of V. cholerae biofilms.
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spelling pubmed-42887012015-01-26 Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae Warner, Christopher J. A. Cheng, Andrew T. Yildiz, Fitnat H. Linington, Roger G. Chem Commun (Camb) Chemistry Bacterial biofilms are estimated to be associated with over 65 percent of all nosocomial infections. However, no therapeutics have been approved by the FDA which directly mediate biofilm formation or persistence. Herein we report oxazine 25 as a highly potent inhibitor, disperser and in the presence of the appropriate antibiotic eradicator of V. cholerae biofilms. Royal Society of Chemistry 2015-01-25 2014-12-05 /pmc/articles/PMC4288701/ /pubmed/25479128 http://dx.doi.org/10.1039/c4cc07003h Text en This journal is © The Royal Society of Chemistry 2014 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Warner, Christopher J. A.
Cheng, Andrew T.
Yildiz, Fitnat H.
Linington, Roger G.
Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae
title Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae
title_full Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae
title_fullStr Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae
title_full_unstemmed Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae
title_short Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae
title_sort development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against vibrio cholerae
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288701/
https://www.ncbi.nlm.nih.gov/pubmed/25479128
http://dx.doi.org/10.1039/c4cc07003h
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AT yildizfitnath developmentofbenzo14oxazinesasbiofilminhibitorsanddispersalagentsagainstvibriocholerae
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