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What Makes a Protein Sequence a Prion?

Typical amyloid diseases such as Alzheimer's and Parkinson's were thought to exclusively result from de novo aggregation, but recently it was shown that amyloids formed in one cell can cross-seed aggregation in other cells, following a prion-like mechanism. Despite the large experimental e...

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Detalles Bibliográficos
Autores principales: Sabate, Raimon, Rousseau, Frederic, Schymkowitz, Joost, Ventura, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288708/
https://www.ncbi.nlm.nih.gov/pubmed/25569335
http://dx.doi.org/10.1371/journal.pcbi.1004013