Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate

The immunogenicity of biotherapeutics can bottleneck development pipelines and poses a barrier to widespread clinical application. As a result, there is a growing need for improved deimmunization technologies. We have recently described algorithms that simultaneously optimize proteins for both reduc...

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Detalles Bibliográficos
Autores principales: Salvat, Regina S., Parker, Andrew S., Choi, Yoonjoo, Bailey-Kellogg, Chris, Griswold, Karl E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288714/
https://www.ncbi.nlm.nih.gov/pubmed/25568954
http://dx.doi.org/10.1371/journal.pcbi.1003988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288714/
https://www.ncbi.nlm.nih.gov/pubmed/25568954
http://dx.doi.org/10.1371/journal.pcbi.1003988

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