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Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate
The immunogenicity of biotherapeutics can bottleneck development pipelines and poses a barrier to widespread clinical application. As a result, there is a growing need for improved deimmunization technologies. We have recently described algorithms that simultaneously optimize proteins for both reduc...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288714/ https://www.ncbi.nlm.nih.gov/pubmed/25568954 http://dx.doi.org/10.1371/journal.pcbi.1003988 |