Cargando…

Hyperreactive Onchocerciasis is Characterized by a Combination of Th17-Th2 Immune Responses and Reduced Regulatory T Cells

Clinical manifestations in onchocerciasis range from generalized onchocerciasis (GEO) to the rare but severe hyperreactive (HO)/sowda form. Since disease pathogenesis is associated with host inflammatory reactions, we investigated whether Th17 responses could be related to aggravated pathology in HO...

Descripción completa

Detalles Bibliográficos
Autores principales:	Katawa, Gnatoulma, Layland, Laura E., Debrah, Alex Y., von Horn, Charlotte, Batsa, Linda, Kwarteng, Alexander, Arriens, Sandra, W. Taylor, David, Specht, Sabine, Hoerauf, Achim, Adjobimey, Tomabu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288720/ https://www.ncbi.nlm.nih.gov/pubmed/25569210 http://dx.doi.org/10.1371/journal.pntd.0003414

Ejemplares similares

Anti-Th17 and anti-Th2 responses effects of hydro-ethanolic extracts of Aframomum melegueta, Khaya senegalensis and Xylopia aethiopica in hyperreactive onchocerciasis individuals’ peripheral blood mononuclear cells
por: Katawa, Gnatoulma, et al.
Publicado: (2022)

Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes
por: Prodjinotho, Ulrich F., et al.
Publicado: (2017)

Elevated Adaptive Immune Responses Are Associated with Latent Infections of Wuchereria bancrofti
por: Arndts, Kathrin, et al.
Publicado: (2012)

Immunoepidemiological Profiling of Onchocerciasis Patients Reveals Associations with Microfilaria Loads and Ivermectin Intake on Both Individual and Community Levels
por: Arndts, Kathrin, et al.
Publicado: (2014)

Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals
por: Arndts, Kathrin, et al.
Publicado: (2015)

Distinct N-Linked Immunoglobulin G Glycosylation Patterns Are Associated With Chronic Pathology and Asymptomatic Infections in Human Lymphatic Filariasis
por: Adjobimey, Tomabu, et al.
Publicado: (2022)

Wuchereria bancrofti-infected individuals harbor distinct IL-10-producing regulatory B and T cell subsets which are affected by anti-filarial treatment
por: Ritter, Manuel, et al.
Publicado: (2019)

Low levels of transforming growth factor-beta (TGF-beta) and reduced suppression of Th2-mediated inflammation in hyperreactive human onchocerciasis
por: KORTEN, S., et al.
Publicado: (2011)

Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial
por: Klarmann-Schulz, Ute, et al.
Publicado: (2017)

Absence of IL-17A in Litomosoides sigmodontis-infected mice influences worm development and drives elevated filarial-specific IFN-γ
por: Ritter, Manuel, et al.
Publicado: (2018)

Immunohistology of ectopic secondary lymph follicles in subcutaneous nodules from patients with hyperreactive onchocerciasis (sowda)
por: Brattig, Norbert W., et al.
Publicado: (2010)

IgG4 antibodies from patients with asymptomatic bancroftian filariasis inhibit the binding of IgG1 and IgG2 to C1q in a Fc-Fc-dependent mechanism
por: Prodjinotho, Ulrich F., et al.
Publicado: (2019)

Whole blood transcriptome analysis in onchocerciasis
por: Lagatie, Ole, et al.
Publicado: (2022)

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study
por: Hoerauf, Achim, et al.
Publicado: (2007)

Helminth antigens differentially modulate the activation of CD4(+) and CD8(+) T lymphocytes of convalescent COVID-19 patients in vitro
por: Adjobimey, Tomabu, et al.
Publicado: (2022)

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study
por: Hoerauf, Achim, et al.
Publicado: (2008)

Human autoantibody to defensin: disease association with hyperreactive onchocerciasis (sowda)
Publicado: (1995)

Assessment of microfilarial loads in the skin of onchocerciasis patients after treatment with different regimens of doxycycline plus ivermectin
por: Debrah, Alexander Yaw, et al.
Publicado: (2006)

Doxycycline Improves Filarial Lymphedema Independent of Active Filarial Infection: A Randomized Controlled Trial
por: Mand, Sabine, et al.
Publicado: (2012)

Reduced Type 2 Innate Lymphocyte Cell Frequencies in Patent Wuchereria bancrofti-Infected Individuals
por: Tamadaho, Ruth S. E., et al.
Publicado: (2023)

Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG)
por: Globisch, Daniel, et al.
Publicado: (2017)

Distinct Immune Profiles of Exhausted Effector and Memory CD8(+) T Cells in Individuals With Filarial Lymphedema
por: Horn, Sacha, et al.
Publicado: (2021)

Filarial Lymphedema Patients Are Characterized by Exhausted CD4(+) T Cells
por: Horn, Sacha, et al.
Publicado: (2022)

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline
por: Debrah, Alexander Yaw, et al.
Publicado: (2011)

Comparison of Repeated Doses of Ivermectin Versus Ivermectin Plus Albendazole for the Treatment of Onchocerciasis: A Randomized, Open-label, Clinical Trial
por: Batsa Debrah, Linda, et al.
Publicado: (2020)

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis
por: Johnston, Kelly L., et al.
Publicado: (2014)

Distinct Schistosoma mansoni-Specific Immunoglobulin Subclasses Are Induced by Different Schistosoma mansoni Stages—A Tool to Decipher Schistosoma mansoni Infection Stages
por: Arndts, Kathrin, et al.
Publicado: (2021)

Doxycycline Reduces Plasma VEGF-C/sVEGFR-3 and Improves Pathology in Lymphatic Filariasis
por: Debrah, Alexander Yaw, et al.
Publicado: (2006)

Comparison of IgA, IgG, and Neutralizing Antibody Responses Following Immunization With Moderna, BioNTech, AstraZeneca, Sputnik-V, Johnson and Johnson, and Sinopharm’s COVID-19 Vaccines
por: Adjobimey, Tomabu, et al.
Publicado: (2022)

Newly acquired Onchocerca volvulus filariae after doxycycline treatment
por: Specht, Sabine, et al.
Publicado: (2009)

Onchocerciasis Control: Vision for the Future from a Ghanian perspective
por: Taylor, Mark J, et al.
Publicado: (2009)

Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial
por: Debrah, Alexander Yaw, et al.
Publicado: (2015)

Ethnobotanical survey, anthelmintic effects and cytotoxicity of plants used for treatment of helminthiasis in the Central and Kara regions of Togo
por: Ataba, Essoham, et al.
Publicado: (2020)

Frequent detection of worm movements in onchocercal nodules by ultrasonography
por: Mand, Sabine, et al.
Publicado: (2005)

Negative association between ascaris lumbricoides seropositivity and Covid-19 severity: insights from a study in Benin
por: Adjobimey, Tomabu, et al.
Publicado: (2023)

Epidemiology of Mansonella perstans in the middle belt of Ghana
por: Debrah, Linda Batsa, et al.
Publicado: (2017)

High Prevalence of Hepatitis B Virus Infection in the Age Range of 20-39 Years Old Individuals in Lome
por: Kolou, Malewe, et al.
Publicado: (2017)

Impact of Helminth Infections on Female Reproductive Health and Associated Diseases
por: Chetty, Alisha, et al.
Publicado: (2020)

Onchocerciasis drug development: from preclinical models to humans
por: Ngwewondo, Adela, et al.
Publicado: (2021)

Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis
por: TAYLOR, MARK J., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pd92p3jjco45tjr86u4cq96m94