Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes

Clinical outcome of children with malignant glioma remains dismal. Here, we examined the role of over-expressed BMI1, a regulator of stem cell self-renewal, in sustaining tumor formation in pediatric glioma stem cells. Our investigation revealed BMI1 over-expression in 29 of 54 (53.7%) pediatric gli...

Descripción completa

Detalles Bibliográficos
Autores principales: Baxter, Patricia A, Lin, Qi, Mao, Hua, Kogiso, Mari, Zhao, Xiumei, Liu, Zhigang, Huang, Yulun, Voicu, Horatiu, Gurusiddappa, Sivashankarappa, Su, Jack M, Adesina, Adekunle M, Perlaky, Laszlo, Dauser, Robert C, Leung, Hon-chiu Eastwood, Muraszko, Karin M, Heth, Jason A, Fan, Xing, Lau, Ching C, Man, Tsz-Kwong, Chintagumpala, Murali, Li, Xiao-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289398/
https://www.ncbi.nlm.nih.gov/pubmed/25526772
http://dx.doi.org/10.1186/s40478-014-0160-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289398/
https://www.ncbi.nlm.nih.gov/pubmed/25526772
http://dx.doi.org/10.1186/s40478-014-0160-4

Ejemplares similares