Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo

Efficient intracellular delivery of proteins is needed to fully realize the potential of protein therapeutics. Current methods of protein delivery commonly suffer from low tolerance for serum, poor endosomal escape, and limited in vivo efficacy. Here we report that common cationic lipid nucleic acid...

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Detalles Bibliográficos
Autores principales: Zuris, John A., Thompson, David B., Shu, Yilai, Guilinger, John P., Bessen, Jeffrey L., Hu, Johnny H., Maeder, Morgan L., Joung, J. Keith, Chen, Zheng-Yi, Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289409/
https://www.ncbi.nlm.nih.gov/pubmed/25357182
http://dx.doi.org/10.1038/nbt.3081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289409/
https://www.ncbi.nlm.nih.gov/pubmed/25357182
http://dx.doi.org/10.1038/nbt.3081

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